Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology

Figure 4 Comparative analysis of the overlapping transcriptomes mapping to severe coronavirus disease 2019 liver tissue, liver cirrhosis, liver fibrosis, and non-alcoholic fatty liver disease. A: Top 20 Genes overlapping between the upregulated transcriptome of severe coronavirus disease 2019 (COVID-19) patients’ liver tissue samples and the signatures of liver cirrhosis, liver fibrosis, and non-alcoholic fatty liver disease retrieved from DisGeNET; gene disease association score was retrieved from DisGeNET and fold change is calculated using AltAnalyze to represent the difference in expression in COVID-19 liver tissue samples vs non-COVID-19 liver samples; B: functional clustering and pathway analysis of the overlapping transcriptome (upregulated and downregulated) of the severe COVID-19 patients’ liver tissues with the disease signature of liver cirrhosis, liver fibrosis, and non-alcoholic fatty liver disease analyzed using Metascape. GDA score: Gene disease association score; F.C.: Fold change.