Prediction of hepatic inflammation in chronic hepatitis B patients with a random forest-backward feature elimination algorithm

Table 1 Clinical characteristics of patients with chronic hepatitis B virus infection

Parameter	HBeAg-positive patients (n = 402)	HBeAg-negative patients (n = 248)	P value
Gender, male	79.4.4% (319/402)	76.2% (189/248)	0.38
Age (yr)	36.35 ± 10.36	41.67 ± 9.65	< 0.001
BMI (kg/m2)	23.12 ± 3.31	23.62 ± 2.84	0.01
HBsAg (log10 IU/mL)	3.83 ± 0.81	3.16 ± 0.73	< 0.001
HBV DNA (log10IU/mL)	6.93 ± 1.66	4.82 ± 1.64	< 0.001
ALT (U/L)	106.74 ± 139.40	80.58 ± 105.61	< 0.001
AST (U/L)	65.48 ± 78.67	56.69 ± 70.06	0.029
TC (mmol/L)	4.61 ± 3.05	4.44 ± 0.98	0.691
TBil (μmol/L)	16.54 ± 15.48	18.49 ± 27.32	0.009
DBil (μmol/L)	5.61 ± 7.54	5.77 ± 6.59	0.527
Albumin (g/L)	43.72 ± 5.14	44.91 ± 6.07	0.011
PT (s)	12.81 ± 1.49	12.55 ± 1.49	0.035
Cr (μmol/L)	70.21 ± 25.41	69.19 ± 15.93	0.818
BUN (mmol/L)	5.28 ± 5.57	4.90 ± 1.33	0.681
Platelet counts (× 109/L)	178.6 ± 56.18	158.5 ± 55.28	< 0.001
Histology (n, %)
HAI 0-4	38.31% (154/402)	44.35% (110/248)	0.14
HAI ≥ 5	61.69% (248/402)	55.64% (138/248)
Fibrosis score 0-2	38.06% (153/402)	59.27% (147/248)	< 0.001
Fibrosis score ≥ 3	61.49% (249/402)	40.73% (101/248)

BMI: Body mass index; HBsAg: Hepatitis B surface antigen; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TC: Total cholesterol; TBil: Total bilirubin; DBil: Direct bilirubin; PT: Prothrombin time; Cr: Creatinine; BUN: Blood urea nitrogen; HAI: Histology activity index.