Molecular alterations in pancreatic tumors

doi:10.3748/wjg.v27.i21.2710

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Jun 7, 2021 (publication date) through Nov 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2021; 27(21): 2710-2726
Published online Jun 7, 2021. doi: 10.3748/wjg.v27.i21.2710

Table 3 Main genetic alterations detectable in other pancreatic tumors

Type of pancreatic lesion	Genetic alteration	Reported frequency (%)	Type of alterations	Role in clinical practice
SPN	CTNNB1	90-100	Point mutations	Diagnostic
PanNET	MEN1	70	Point mutations/LOH	Diagnostic/prognostic
PanNET	VHL	25	Point mutations/LOH	Diagnostic
AAC	CTNNB1	5-25	Point mutationsLOF	Diagnostic
AAC	MSI	5-15	LOF	Predictive?

The percentages quoted are estimated from the literature cited in the paper. Diagnostic role appears mainly in preoperative material. SPN: Solid pseudopapillary neoplasm; PanNET: Pancreatic neuroendocrine tumor; AAC: Acinic adenocarcinoma; LOH: Loss of heterozygosity; LOF: Loss of function.

Citation: Visani M, Acquaviva G, De Leo A, Sanza V, Merlo L, Maloberti T, Brandes AA, Franceschi E, Di Battista M, Masetti M, Jovine E, Fiorino S, Pession A, Tallini G, de Biase D. Molecular alterations in pancreatic tumors. World J Gastroenterol 2021; 27(21): 2710-2726
URL: https://www.wjgnet.com/1007-9327/full/v27/i21/2710.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i21.2710