Molecular alterations in pancreatic tumors

doi:10.3748/wjg.v27.i21.2710

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Jun 7, 2021 (publication date) through Nov 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2021; 27(21): 2710-2726
Published online Jun 7, 2021. doi: 10.3748/wjg.v27.i21.2710

Table 1 Main genetic alterations detectable in pancreatic ductal adenocarcinoma

Type of pancreatic lesion	Genetic alteration	Reported frequency (%)	Type of alterations	Role in clinical practice
PDAC	KRAS	70-90	Point mutations	Diagnostic/prognostic
	TP53	50-75	Point mutations/LOH	Prognostic
	CDKN2A/p16	90-98	Point mutations/LOH	Prognostic/genetic surveillance
	SMAD4	40-60	Point mutations/LOH	Prognostic
	BRCA1/2	5-10	Point mutations	Predictive/genetic surveillance
	NTRK1-3	< 1	Gene fusions	Predictive
	MSI	< 2	LOF	Predictive

The percentages quoted are estimated from the literature cited in the paper. Diagnostic role appears mainly in preoperative material. In bold those markers recommended for clinical practice by National Comprehensive Cancer Network 2019 guidelines. PDAC: Pancreatic ductal adenocarcinoma; LOH: Loss of heterozygosity.

Citation: Visani M, Acquaviva G, De Leo A, Sanza V, Merlo L, Maloberti T, Brandes AA, Franceschi E, Di Battista M, Masetti M, Jovine E, Fiorino S, Pession A, Tallini G, de Biase D. Molecular alterations in pancreatic tumors. World J Gastroenterol 2021; 27(21): 2710-2726
URL: https://www.wjgnet.com/1007-9327/full/v27/i21/2710.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i21.2710