Open reading frame 3 protein of hepatitis E virus: Multi-function protein with endless potential

Figure 3 Regulation of host innate immune response by hepatitis E virus-open reading frame 3 proteins. A: Promotion of retinoic acid-inducible gene I mediated activation by hepatitis E virus (HEV)-open reading frame (ORF) 3; B: Inhibition of Toll-like receptor (TLR) 3 and TLR7 by HEV-ORF3; C: Blocking of the phosphorylation of signal transducer and activator of transcription (STAT) 1 to inhibit Janus kinase/STAT signaling. RIG-I: Retinoic acid-inducible gene I; RIP-I: Ribosome-inactivating proteins type I; FADD: Fas-associated protein with death domain; IKK: IkappaB kinase; TBK: Tank-Binding-Kinase; IRF: Interferon regulatory factor; NF-kB: Nuclear factor kB; IFN: Interferon; TLR: Toll-like receptor; TRIF: Toll-interleukin 1 receptor domain-containing adapter inducing interferon-beta; NAPI: Net anthropogenic phosphorus input; IFNAR: Inflammation-the type I interferon receptor; JAK: Janus kinase; TYK: Targeting tyrosine kinase; STAT: Signal transducer and activator of transcription; ISGF: Interferon-stimulated gene factor; ISRE: Interferon-stimulated response element; ISGs: Interferon-stimulated genes; CBP: CREB-binding protein.