Development and validation of a prognostic model for patients with hepatorenal syndrome: A retrospective cohort study

Table 2 Univariate and multivariate Cox regression.

Variables	Univariate Cox regression		Multivariate Cox regression
	HR (95%CI)	P value	HR (95%CI)	P value
Age	1.007 (0.995-1.019)	0.244
Gender	0.586 (0.425-0.807)	0.001	0.532 (0.384-0.737)	< 0.001
Causes of cirrhosis	0.946 (0.785-1.140)	0.557
MAP	0.990 (0.981-0.999)	0.024
INR	1.842 (1.599-2.122)	< 0.001	1.408 (1.173-1.691)	< 0.001
Neutrophil	1.028 (1.015-1.041)	< 0.001	1.031 (1.018-1.044)	< 0.001
RBC	1.137 (0.959-1.348)	0.139
Hemoglobin	1.007 (1.002-1.012)	0.012
MCV	1.004 (0.988-1.021)	0.599
MCH	1.066 (1.022-1.111)	0.003
MCHC	1.019 (1.010-1.027)	< 0.001	1.014 (1.005-1.022)	0.002
Platelet	0.997 (0.994-1.000)	0.090
Albumin	1.000 (0.973-1.028)	0.999
A/G	1.257 (1.093-1.445)	0.001
ALT	1.000 (1.000-1.001)	0.094
Serum bilirubin	1.002 (1.001-1.003)	< 0.001
Cholinesterase	1.000 (0.999-1.000)	0.160
Creatinine	1.000 (0.999-1.001)	0.704
Sodium	0.960 (0.939-0.982)	< 0.001
Potassium	1.215 (1.032-1.430)	0.019
Stage	3.805 (2.800-5.170)	< 0.001	2.724 (1.877-3.952)	< 0.001
MELD	1.077 (1.058-1.096)	< 0.001
CLIF-SOFA	1.221 (1.166-1.278)	< 0.001
COSSH-ACLF	1.467 (1.361-1.581)	< 0.001

A/G: Albumin/globulin; ALT: Alanine aminotransferase; CI: Confidence interval; CLIF-SOFA: Chronic liver failure-sequential organ failure assessment; COSSH-ACLF: Chinese Group on the study of severe hepatitis B-acute-on-chronic liver failure; HR: Hazard ratio; INR: International normalized ratio; MAP: Mean arterial pressure; MCH: Mean cell hemoglobin; MCHC: Mean corpuscular hemoglobin concentration; MCV: Mean cell volume; MELD: Model for end-stage liver disease; RBC: Red blood cells.