Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis

Figure 1 Effects of partially hydrolyzed guar gum on the non-alcoholic fatty liver disease model. A: Representative macroscopic findings in the liver. Non-alcoholic fatty liver disease was induced in mice subjected to the atherogenic diet with increased intestinal permeability for 8 wk; B: Representative histological findings in the liver. Magnification, × 100. Hematoxylin and eosin staining; C: Myeloperoxidase (MPO) activity. The liver was homogenized and MPO activity was determined as an index of neutrophil accumulation in the liver. Data represent the mean ± SD of seven mice. ^aP < 0.05 significant differences compared to the control group; ^bP < 0.05 significant differences between the 2 selected groups. NAFLD: Non-alcoholic fatty liver disease; PHGG: Partially hydrolyzed guar gum; MPO: Myeloperoxidase.