Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria

Table 4 Univariate and multivariate models for recurrence

	Univariate analysis	Multivariate analysis
	P value	RR (95%CI)	P value
RFA	0.001	1.37 (1.17-1.60)	0.0001
Age ≤ 75 yr	0.28
Male	0.91
Co-morbidity ≥ 2	0.01
BMI < 24	0.61
ASA score III-IV	0.61
Bilirubin (mg/dL > 2)	0.37
Creatinine (mg/dL > 1)	0.62
PLT (U/μL > 150 × 10³)	0.001
INR (> 1.3)	0.02
Tumor size < 3 cm	0.001
Multiple nodule	0.07
Child Pugh A	0.26
MELD > 10	0.01	1.51 (1.04-2.17)	0.03

The relative prognostic significance of the variables in predicting overall survival and overall recurrence was established using univariate and multivariate Cox proportional hazards regression models. Radiofrequency ablation and Model for End-Stage Liver Disease score > 10 were considered poor prognostic factors. RFA: Radiofrequency ablation; INR: International normalized ratio; MELD: Model for End-Stage Liver Disease; RR: Relative risk; CI: Confidence interval; BMI: Body mass index; ASA: American Society of Anesthesiologists; PLT: Platelets.