Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria

Table 3 Univariate and multivariate models for survival

	Univariate analysis	Multivariate analysis
	P value	RR (95%CI)	P value
RFA	0.001	1.46 (1.1-1.79)	0.001
Age ≤ 75 yr	0.63
Male	0.001
Co-morbidity ≥ 2	0.001
BMI < 24	0.001
ASA score III-IV	0.07
TBil (mg/dL > 2)	0.001
Crea (mg/dL > 1)	0.57
PLT (U/μL > 150 × 10³)	0.001
INR (> 1.3)	0.001	1.60 (1.03-2.49)	0.03
Tumor size < 3 cm	0.001
Multiple nodule	0.001	1.19 (1.08-4.17)	0.03
Child Pugh A	0.001
MELD > 10	0.007	1.89 (1.21-2.92)	0.005

The relative prognostic significance of the variables in predicting overall survival and overall recurrence was established using univariate and multivariate Cox proportional hazards regression models. Radiofrequency ablation, international normalized ratio > 1.3 mg/dL, and Model for End-Stage Liver Disease score >10 were independent risk factors for overall survival. RFA: Radiofrequency ablation; INR: International normalized ratio; MELD: Model for End-Stage Liver Disease; RR: Relative risk; CI: Confidence interval; BMI: Body mass index; ASA: American Society of Anesthesiologists; PLT: Platelets; TBil: Total bilirubin; Crea: Creatinine.