Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis

doi:10.3748/wjg.v27.i18.2160

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May 14, 2021 (publication date) through Jul 21, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2021; 27(18): 2160-2176
Published online May 14, 2021. doi: 10.3748/wjg.v27.i18.2160

Table 4 Partially hydrolyzed guar gum-mediated profiles of short-chain fatty acids in cecal contents

Short chain fatty acids (mmol/g)	Control	Control + PHGG	NAFLD	NAFLD + PHGG
Succinic acid	0.82 ± 0.34	0.85 ± 0.36	5.08 ± 2.27^a	5.28 ± 2.20^a
Lactic acid	0.05 ± 0.08	0.09 ± 0.13	0.40 ± 0.46^a	0.45 ± 0.39^a
Formic acid	0.89 ± 0.09	1.90 ± 0.06^a	0.72 ± 0.16^a	0.83 ± 0.28^b
Acetic acid	41.2 ± 6.0	47.9 ± 8.8^a	32.8 ± 5.3^a	33.1 ± 7.9^a
Propionic acid	8.18 ± 1.14	9.16 ± 1.04^a	9.76 ± 2.56^a	9.82 ± 3.39^a
Isobutyric acid	1.19 ± 0.11	1.04 ± 0.11	1.44 ± 0.20^a	1.06 ± 0.28^b
Butyric acid	8.86 ± 2.42	13.81 ± 5.14^a	3.91 ± 0.58^a	3.34 ± 1.09^a
Isovaleric acid	0.33 ± 0.14	0.12 ± 0.11^a	1.05 ± 0.40^a	0.38 ± 0.40^b
Valeric acid	0.49 ± 0.18	0.48 ± 0.14	0.50 ± 0.22	0.18 ± 0.17^a^,^b

Data are presented as the mean ± SD.

^aP < 0.05 significant differences compared to the control group.

^bP < 0.05 significant differences between the non-alcoholic fatty liver disease (NAFLD) group and the NAFLD + Partially hydrolyzed guar gum group. PHGG: Partially hydrolyzed guar gum; NAFLD: Non-alcoholic fatty liver disease.

Citation: Takayama S, Katada K, Takagi T, Iida T, Ueda T, Mizushima K, Higashimura Y, Morita M, Okayama T, Kamada K, Uchiyama K, Handa O, Ishikawa T, Yasukawa Z, Okubo T, Itoh Y, Naito Y. Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis. World J Gastroenterol 2021; 27(18): 2160-2176
URL: https://www.wjgnet.com/1007-9327/full/v27/i18/2160.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i18.2160