Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis

doi:10.3748/wjg.v27.i18.2160

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May 14, 2021 (publication date) through Jul 21, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2021; 27(18): 2160-2176
Published online May 14, 2021. doi: 10.3748/wjg.v27.i18.2160

Table 3 Characteristics of the experimental groups

Characteristics	Control	Control + PHGG	NAFLD	NAFLD + PHGG
Body weight (g)	25.7 ± 0.5	25.2 ± 1.1	20.6 ± 0.8^a	20.8 ± 1.6^a
Liver weight (g)	1.17 ± 0.05	1.03 ± 0.08	1.47 ± 0.11^a	1.55 ± 0.13^a
Liver weight (% body)	4.45 ± 0.13	4.13 ± 0.32	7.13 ± 0.40^a	7.44 ± 0.61^a
Aspartate aminotransferase (IU/L)	72.0 ± 7.1	73.1 ± 11.9	133.1 ± 69.1^a	83.5 ± 24.1^a^,^b
Alanine aminotransferase (IU/L)	23.4 ± 2.9	20.0 ± 3.4	112.9 ± 77.0^a	46.3 ± 15.9^a^,^b
Total cholesterol (mg/dL)	97.7 ± 6.6	83.7 ± 10.8	359.7 ± 95.0^a	306.7 ± 26.5^a
Triglyceride (mg/dL)	88.9 ± 25.4	71.1 ± 25.1	16.6 ± 4.0^a	36.2 ± 25.7^a^,^b
Free fatty acids (mEQ/L)	1668 ± 257	1334 ± 254^a	1254 ± 201^a	1119 ± 310^a
Glucose (mg/dL)	70 ± 53	73 ± 16	73 ± 19	95 ± 32

Data are presented as the mean ± SD.

^aP < 0.05 significant differences compared to the control group.

^bP < 0.05 significant differences between the non-alcoholic fatty liver disease (NAFLD) group and the NAFLD + Partially hydrolyzed guar gum group. Non-alcoholic fatty liver disease group was induced by high fat diet with increased intestinal permeability. NAFLD: Non-alcoholic fatty liver disease; PHGG: Partially hydrolyzed guar gum.

Citation: Takayama S, Katada K, Takagi T, Iida T, Ueda T, Mizushima K, Higashimura Y, Morita M, Okayama T, Kamada K, Uchiyama K, Handa O, Ishikawa T, Yasukawa Z, Okubo T, Itoh Y, Naito Y. Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis. World J Gastroenterol 2021; 27(18): 2160-2176
URL: https://www.wjgnet.com/1007-9327/full/v27/i18/2160.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i18.2160