Neurological manifestations of hepatitis E virus infection: An overview

Table 2 Relationship of hepatitis E virus infection with extrahepatic manifestations

Extrahepatic manifestations	Likelihood of causal relationship, Hill criteria[9,97]	Evidence to support a casual role
Neurological disorders
Neuralgic amyotrophy	Very probable	Good
Guillain-Barré syndrome	Very probable	Good
Meningoencephaltis	Very probable	Good
Others1	Possible/under debate	Remains to be established
Kidney disorders
Membranoproliferative glomerulonephritis	Very probable	Good
Membranous glomerulonephritis	Very probable	Good
IgA nephropathy	Very probable	Good
Gastrointestinal disorder
Acute pancreatitis	Very probable	Remains to be established
Hematological diseases
Thrombocytopenia, monoclonal gammopathy of uncertain significance, Cryoglobulinemia, hemolytic anemia, aplastic anemia	Possible	Remains to be established
Miscellaneous
Autoimmune hepatitis, myocarditis, thyroiditis	Doubtful/under debate	Remains to be established

¹See Table 3 for other neurological disorders. IgA: Immunoglobulin A.