Hepatocellular carcinoma progression in hepatitis B virus-related cirrhosis patients receiving nucleoside (acid) analogs therapy: A retrospective cross-sectional study

doi:10.3748/wjg.v27.i17.2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. May 7, 2021; 27(17): 2025-2038
Published online May 7, 2021. doi: 10.3748/wjg.v27.i17.2025

Table 1 Comparison of the clinical characteristics of patients with and without hepatocellular carcinoma

Characteristic	no-HCC group (n = 145)	HCC group (n = 121)	P value
Age ≥ 60 yr, n (%)	41 (28.3)	64 (52.9)	< 0.001
Male, n (%)	99 (68.3)	91 (75.2)	0.133
Etiology of liver cirrhosis, n (%)
HBV	101 (60.7)	76 (62.8)	0.363
HBV + alcohol	31 (21.4)	45 (37.2)	0.006
HBV + HEV	1 (0.6)	0 (0.0)	-
HBV + schistosome	1 (0.6)	0 (0.0)	-
Smoking history, n (%)	21 (14.5)	51 (42.1)	< 0.001
Family history of HBV-related HCC, n (%)	10 (6.9)	23 (19.0)	0.004
Medication history
Duration of NA treatment, yr, median (P₂₅, P₇₅)	3.9 (2.1, 5.8)	5.4 (2.3, 6.9)	0.067
LAM resistance, n (%)	18 (12.4)	27 (22.3)	0.021
HBsAg level, IU/L, median (P₂₅, P₇₅)	255.0 (56.0, 678.0)	269.0 (67.0, 656.0)	0.456
HBeAg positive, n (%)	37 (25.5)	21 (17.4)	0.136
HBV DNA negative, n (%)	67 (46.2)	39 (32.2)	0.033
ALB, U/L	36.29 ± 7.98	33.34 ± 6.62	0.002
ALT, U/L, median (P₂₅, P₇₅)	27.00 (18.00, 37.00)	32.00 (21.27, 62.00)	0.006
AST, U/L, median (P₂₅, P₇₅)	33.00 (23.00, 47.00)	44.50 (31.65, 96.85)	< 0.001
GGT, U/L, median (P₂₅, P₇₅)	33.00 (20.00, 46.00)	61.50 (32.75, 160.75)	< 0.001
ALP, U/L, median (P₂₅, P₇₅)	99.00 (73.00, 126.00)	134.50 (92.00, 198.85)	< 0.001
TB, μmol/L, median (P₂₅, P₇₅)	20.41 (13.81, 44.60)	24.46 (16.60, 42.80)	0.192
FBS, mmol/L, median (P₂₅, P₇₅)	5.17 ± 0.68	6.99 ± 1.31	0.025
Ascites, n (%)	33 (20.0)	43 (34.7)	0.022
Child-Pugh class, n (%)
A	81 (55.9)	55 (45.5)	0.001
B	38 (26.2)	26 (21.5)	0.561
C	26 (17.9)	40 (33.1)	0.002
AFP ≥ 20 μg/L, n (%)	14 (9.7)	56 (46.3)	< 0.001
PT s, median (P₂₅, P₇₅)	13.25 (11.80, 14.20)	13.51 (12.41, 15.02)	0.475

AFP: Alpha-fetoprotein; ALB: Albumin; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; FBS: Fasting blood sugar; GGT: Glutamyl transpeptidase; HBeAb: Hepatitis B e-antibody; HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; LAM: Lamivudine; PT: Prothrombin time; SD: Standard deviation; TB: Total bilirubin.

Citation: Yang DH, Wang WP, Zhang Q, Pan HY, Huang YC, Zhang JJ. Hepatocellular carcinoma progression in hepatitis B virus-related cirrhosis patients receiving nucleoside (acid) analogs therapy: A retrospective cross-sectional study. World J Gastroenterol 2021; 27(17): 2025-2038
URL: https://www.wjgnet.com/1007-9327/full/v27/i17/2025.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i17.2025