S100 calcium binding protein A6 and associated long noncoding ribonucleic acids as biomarkers in the diagnosis and staging of primary biliary cholangitis

Table 5 Characteristics of primary biliary cholangitis patients based on the expression of log10 LINC00472 cutoff value

	Relative Expression of log10 LINC00472
	L1 (< 2.33) (n = 38)	L2 (≥ 2.33) (n = 42)	P value
Age, mean ± SD, years	60.3 ± 14.9	55.1 ± 14.0	0.109
Gender, n (%)
Male	5 (13.2)	5 (11.9)
Female	33 (86.8)	37 (88.1)	0.886
ALT, U/L	73.2 (52.7-100.1)	73.2 (46.2-100.7)	0.985
AST, U/L	109.2 ± 45.9	103.0 ± 44.6	0.543
ALP, U/L	264.0 ± 89.4	252.2 ± 78.3	0.532
γGT, U/L	420.2 ± 197.9	413.2 ± 237.1	0.887
TBA, μmol/L	73.2 ± 12.4	70.9 ± 13.3	0.438
TBiL, μmol/L	68.0 (63.0-73.0)	63.0 (58.0-73.0)	0.166
DBiL, μmol/L	50.6 ± 9.8	52.2 ± 11.4	0.505
LINC00312	1.51 ± 0.32	1.43 ± 0.31	0.261
S100A6	2.40 ± 1.05	3.57 ± 0.66	< 0.0001
LINC01257	4.25 ± 1.39	3.22 ± 1.78	0.005
HA, ng/mL	144.8 (101.6-208.8)	135.5 (95.4-195.4)	0.537
LN, ng/mL	126.1 (48.4-178.4)	156.1 (57.6-175.8)	0.78
C-IV, ng/mL	127.2 (100.9-170.4)	176.0 (154.7-232.0)	< 0.0001
PC-III, ng/mL	156.6 (125.8-190.1)	161.6 (128.0-184.5)	0.916

SD: Standard deviation; γGT: Gamma-glutamyl transpeptidase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; AST: Aspartate aminotransferase; C-IV: Collagen type IV; DBIL: Direct bilirubin; HA: Hyaluronic acid; LN: Laminin; PC-III: Procollagen III; S100A6: S100 calcium binding protein A6; TBA: Total bile acid; TBIL: Total bilirubin.