Mitochondrial pathway of the lysine demethylase 5C inhibitor CPI-455 in the Eca-109 esophageal squamous cell carcinoma cell line

Figure 2 Changes in Eca109 cells after 48 h culture with and without CPI-455 treatment. Left panels show the morphology of the mitochondria of Eca109 cells. A: Arrows indicate mitochondria with complete and clear structure. B: Arrows indicate mitochondria with a fuzzy structure and weak staining of cells. Right panels show TUNEL assay results (bar = 10 μm) and laser confocal scanning microscopy × 600 of nuclear staining and DNA fragmentation of Eca109 cells C: without, and D: with CPI-455 treatment. Data are reported as means ± SE (n = 3).