Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric ligation-induced gastroduodenal ulcer in rats

Figure 4 Volcano plots of microarray data on differentially expressed mRNA in gastric and duodenal tissue. A and B: There were 1415 and 1460 differentially expressed genes in the sham operation vs pyloric ligation (PL) (A) and PL vs SL-4 groups (B), respectively in gastric tissue; C and D: There were 2610 and 209 differentially expressed genes in the sham operation vs PL (C) and PL vs SL-4 groups (D), respectively in duodenal tissue. Vertical lines correspond to 2-fold up- and downregulation. The horizontal line represents a P value of 0.05. Significantly up- and downregulated genes are shown in red and green, respectively. Statistical significance was defined as a fold-change of 2.0 and P value of 0.05 between groups. Sham: Sham operation, SL-4: Sulongga-4 decoction.