Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric ligation-induced gastroduodenal ulcer in rats

Table 4 Sequence of major genes involved in two main Kyoto Encyclopedia of Genes and Genomes pathways in gastric and duodenal tissue

Tissue pathway	Gene symbol	Gene name	Sham vs PL	PL vs SL-4	GeneBank accession No.
Gastric (retinol metabolism)	UGT2b1	UDP glucuronosyl transferase 2 family, polypeptide B1"	+13.71	-30.56	NM_173295
	SDR16c5	Short chain dehydrogenase/reductase family 16C, member 5	+7.16	+3.12	NM_001106634
	RDH7	Retinol dehydrogenase 7	+5.89	-45.38	NM_133543
	CYP2b2	Cytochrome P450, family 2, subfamily b, polypeptide 2	+5.57	-12.51	NM_001198676
	CYP4a1	Cytochrome P450, family 4, subfamily a, polypeptide 1	+3.93	-83.27	NM_175837
	CYP1a1	Cytochrome P450, family 1, subfamily a, polypeptide 1	-3.47	+1.86	NM_012540
Duodenal (complement and coagulation cascades)	A2m	Alpha-2-macroglobulin	-20.37	+33.00	NM_012488
	FGG	Fibrinogen gamma chain	-41.01	+15.50	NM_012559
	FGA	Fibrinogen alpha chain	-23.51	+6.49	NM_001008724
	MASP1	Mannan-binding lectin serine peptidase 1	-11.09	+3.19	AY149996
	VSIG4	V-set and immunoglobulin domain containing 4	-6.37	+3.26	NM_001025004
	CFB	Complement factor B	+3.08	-5.43	NM_212466

Genes involved in the retinol metabolism pathway in gastric tissue and in the complement and coagulation cascade pathways in duodenal tissue with > 2-fold change associated with different experimental treatments were determined by microarray analysis. Fold-induction was calculated as the normalized intensity in the study groups. Positive and negative numbers represent up- and downregulated gene expression. PL: Pyloric ligation; Sham: Sham operation; SL-4: Sulongga-4 decoction.