Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease

Figure 2 MicroRNA sequencing profiling and bioinformatic analysis. A: Heatmap of differentially-expressed microRNAs (DE-miRs) in the microRNA sequencing; B: Volcano map of DE-miR expression in the miRNA sequencing; C: GO function analysis for target genes regulated by DE-miRs; D: Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of target genes for the DE-miR. Exo-PA-1/Exo-PA-2: Group 1/2 of exosomes derived from palmitic acid treated primary hepatocytes; Exo-CN-1/Exo-CN-2: Group 1/2 of exosomes derived from vehicle control treated primary hepatocytes.