Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections

Table 3 Estimated differences in alpha diversity indices between the following groups

Variable	Sobs		ShannonH		ShannonE
	Estimate (95%CI)	P value	Estimate (95%CI)	P value	Estimate (95%CI)	P value
Tumor vs nontumor	-1.34 (-4.04, 1.35)	0.32	-0.05 (-0.25, 0.15)	0.61	-0.004 (-0.04, 0.03)	0.77
Pre-op antibiotics vs none	2.93 (-3.51, 9.37)	0.36	0.27 (-0.12, 0.66)	0.17	0.04 (-0.02, 0.09)	0.20
Left vs right	2.83 (-2.44, 8.10)	0.29	-0.10 (-0.43, 0.23)	0.53	-0.03 (-0.08, 0.02)	0.26
Diabetic vs nondiabetic	3.73 (-2.30, 9.75)	0.22	0.26 (-0.11, 0.62)	0.16	0.03 (-0.02, 0.09)	0.22
Black/AA race vs not Black/AA race	2.70 (-4.43, 9.83)	0.45	0.09 (-0.34, 0.52)	0.69	0.01 (-0.06, 0.07)	0.80

Linear mixed models were used to estimate differences. The P values are based on t-tests from the linear mixed models. CI: Confidence interval; AA: African Ancestry.