Global research trends in the microbiome related to irritable bowel syndrome: A bibliometric and visualized study

Table 3 Top 20 most cited articles on the microbiome in irritable bowel syndrome research in the last two decades (2000-2019)

SCR	Ref.	Title	Year	Source title	Cited by
1st	Roberfroid et al[49]	"Prebiotic effects: Metabolic and health benefits"	2010	British Journal of Nutrition	1147
2nd	O'Mahony et al[44]	"Lactobacillus and Bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles"	2005	Gastroenterology	1042
3rd	Claesson et al[37]	"Composition, variability, and temporal stability of the intestinal microbiota of the elderly"	2011	Proceedings of the National Academy of Sciences of the United States of America	836
4th	Collins et al[38]	"The interplay between the intestinal microbiota and the brain”	2012	Nature Reviews Microbiology	735
5th	Kassinen et al[40]	"The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects”	2007	Gastroenterology	684
6th	Pimentel et al[46]	"Rifaximin therapy for patients with irritable bowel syndrome without constipation"	2011	New England Journal of Medicine	659
7th	Rinttilä et al[48]	"Development of an extensive set of 16S rDNA-targeted primers for quantification of pathogenic and indigenous bacteria in faecal samples by real-time PCR"	2004	Journal of Applied Microbiology	658
8th	O'Mahony et al[45]	"Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses "	2009	Biological Psychiatry	634
9th	Rolfe[50]	“The role of probiotic cultures in the control of gastrointestinal health”	2000	Journal of Nutrition	584
10h	Carabotti et al[36]	“The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems"	2015	Annals of Gastroenterology	580
11th	De Vrese and Schrezenmeir[39]	"Probiotics, prebiotics, and synbiotics"	2008	Advances in Biochemical Engineering/Biotechnology	575
12th	Rajilić-Stojanović et al[47]	"Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome"	2011	Gastroenterology	545
13th	Whorwell et al[55]	"Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome"	2006	American Journal of Gastroenterology	541
13th	Swidsinski et al[54]	"Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease"	2005	Journal of Clinical Microbiology	541
15th	Malinen et al[41]	"Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR"	2005	American Journal of Gastroenterology	523
16th	Mayer et al[42]	"Gut/brain axis and the microbiota"	2015	Journal of Clinical Investigation	519
17th	Simrén et al[52]	"Intestinal microbiota in functional bowel disorders: A Rome foundation report"	2013	Gut	510
18th	Spiller and Garsed[53]	"Postinfectious irritable bowel syndrome "	2009	Gastroenterology	508
19th	Rousseaux et al[51]	"Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors"	2007	Nature Medicine	500
20th	Nobaek et al[43]	"Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome"	2000	American Journal of Gastroenterology	498