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Copyright ©The Author(s) 2021.
World J Gastroenterol. Apr 7, 2021; 27(13): 1296-1310
Published online Apr 7, 2021. doi: 10.3748/wjg.v27.i13.1296
Table 2 Summary of specific European Association for the Study of the Liver, European Society of Clinical Microbiology and Infectious Diseases and American Association for the Study of Liver Diseases guidelines and recommendations for the clinical care and management of patients with liver diseases during coronavirus disease 2019 pandemic
Hospitalization and severe COVID-19
Alterations to standard treatment strategies
Progression of liver disease

Early administration, laboratory findings and risk of SARS-CoV-2 infection
Treatment of higher risk groups
Resumption of targeted treatment and surveillance
Patient education and intensive lifestyle advice
NAFLDHigh prevalence risk of SARS-CoV-2 infection in NAFLD patients with COVID-19 suggest an early admission to the hospitalNo side effects related to ACE inhibitors or AR blockers to date, thus, arterial hypertension treatment should continue in accordance to prescribed guidelinesNot well knownIntensive lifestyle interventions including nutritional guidance, weight loss and diabetes management may prevent the risk of severe COVID-19 complications
Chronic Viral HepatitisPatients on chronic HBV or HCV medications with poor compliance should observed treatment protocols, directly(1) In HBV and COVID-19 patients, an alternative agent should be considered rather than interferon-α therapy; (2) COVID-19 patients with high risk of severe acute HCV should consider for an appropriate antiviral therapy on case-by-case basis under the full consultation; and (3) COVID-19 patients with resolved HBV infection, receiving corticosteroids, tocilizumab, or other immunosuppressant agents should be considered for appropriate antiviral therapy to prevent viral reactivation under full consultation(1) Without COVID-19, the patients should continue the HBV or HCV medications in accordance to general guidelines; and (2) in COVID-19 patients, initiation of HBV or HCV medication should be deferred until full recovery from COVID-19 or on case-by-case basis under the full consultationUse of telemedicine for patients of on-going chronic HBV or HCV treatment without COVID-19
Autoimmune hepatitis(1) Immunocompromised patients on corticosteroid treatment during COVID-19 requires respiratory support; And (2) patients on respiratory support may be considered for addition of, or conversion to, dexamethasone treatment(1) Patients on high doses of corticosteroid may show more susceptibility to SARS-CoV-2 infection or severe COVID-19; (2) Low doses may be considered under special circumstances (e.g., drug-induced lymphopenia, or bacterial/fungal superinfection with severe COVID-19) under consultation with specialist; (3) or may consider budesonide as an alternative first line agent in patient without cirrhosis to induce remission who have a flare of autoimmune hepatitisImmunocompromised patients with COVID-19 may be considered for dosing of corticosteroid, sufficient for adrenal insufficiencyAll patients should receive vaccination of Streptococcus pneumoniae and influenza
Alcohol-related liver hepatitisAlcohol-induced severe hepatitis patients on corticosteroid treatment with COVID-19 require respiratory supportNot well knownNot well knownIncreased probability of higher alcohol consumption during social distancing, so, preemptive strategies including patient outreach and telephone alcohol liaison, should be considered
Cirrhosis(1) Cirrhotic patients with COVID-19 should be considered for early hospitalization; and (2) to avoid admission and to prevent decompensation, guidelines on prophylaxis of spontaneous bacterial peritonitis, gastrointestinal hemorrhage and hepatic encephalopathy should be followedVasoconstriction therapy should be considered with great caution for critically ill cirrhotic patients with COVID-19Cirrhotic patients are vulnerable to both SARS-CoV-2 infection and altered standards of patient care during pandemic. Thus, the best efforts should be made for care of cirrhotic patients according to general guidelinesAll patients should receive vaccination of Streptococcus pneumoniae and influenza
Hepatocellular carcinomaSpecific risk of HCC patients with COVID-19 remains undefinedIn COVID-19 patients, initiation of HBV or HCV medication should be deferred until full recovery from COVID-19 or on case-by-case basis under the full consultationFull HCC surveillance should resume under specific circumstancesConsider virtual patient visits to discuss diagnosis and management of HCC and other liver tumors
Liver transplant candidatesPatients on the liver transplant waiting list with decompensated cirrhosis are at high risk of severe COVID-19 and death following SARS-CoV-2 infectionPrecautions should be followed to make COVID-19 free liver transplantation processNot well knownPatients should avoid attending in-person community recovery support meetings, such as Alcoholics Anonymous, and provide alternative telephone or online resources
Liver transplant recipientsEarly admission should be considered for all liver transplant recipients who develop COVID-19Drug levels of calcineurin inhibitors and mechanistic target of rapamycin inhibitors should be closely monitored on administration with COVID-19 medications, particularly hydroxychloroquine, protease inhibitors or new trial drugs for COVID-19Reduction of immunosuppressant dosing may be considered under special circumstances (e.g., drug-induced lymphopenia, or bacterial/fungal superinfection with severe COVID-19) under consultation with specialistAll patients should receive vaccination of Streptococcus pneumoniae and influenza