Primary localized gastric amyloidosis: A scoping review of the literature from clinical presentations to prognosis

Figure 6 A diagnostic procedure from the perspective of clinicians. When a patient arrives at the hospital with suspected digestive symptoms, clinicians should initially perform endoscopy. Relevant endoscopic manifestations should lead to a biopsy examination to detect the existence of amyloid using Congo red staining. If a negative result is obtained, a screen for cancers is recommended, given the resemblance of their clinical manifestations. For a positive result, clinicians should identify the amyloid protein subtype. Then, a series of tests must be chosen by clinicians according to the patient’ conditions to exclude the systemic involvement of amyloidosis. Finally, a diagnosis of localized gastric amyloidosis is determined.