Primary localized gastric amyloidosis: A scoping review of the literature from clinical presentations to prognosis

Figure 3 Potential molecular events leading to amyloidosis. Without intervention, the unfolded protein becomes the normal protein. Factors such as aging, mutation, and high blood concentrations may cause protein misfolding. The misfolded protein aggregates into oligomers and forms fibrils with the assistance of glycosaminoglycans and serum amyloid P. Massive deposition of amyloid fibrils leads to amyloidosis. GAGs: Glycosaminoglycans; SAP: Serum amyloid P.