Hepatitis E in solid organ transplant recipients: A systematic review and meta-analysis

Table 1 Subgroup analyses of all variables

Subgroup	n (%)	Incidence (%)	95%CI
Year
< 2015	10	17.1	9.9-27.9
≥ 2015	8	26.8	19.5-35.7	Q = 2.248, P = 0.134
Country
High-income	16	18.9	13.1-26.4
Middle-income	2	41.8	37.6-46.1	Q = 22.375, P < 0.001c
Study type
Prospective	6	22.3	13.4-34.7
Retrospective	12	20.3	12.8-30.7	Q = 0.077, P = 0.782
Sample size
n < 400	14	25.4	18.9-33.1
n ≥ 400	4	10.4	3.2-28.8	Q = 2.613, P = 0.106
Mean age
≤ 50 yr	3	17.7	5.4-44.8
> 50 yr	10	20.2	13.4-29.3	Q = 0.051, P = 0.821
Male proportion
≤ 65%	7	16.0	7.7-30.4
> 65%	5	23.0	12.5-38.5	Q = 0.631, P = 0.427
Diagnostic test
More than one marker	11	25.9	19-34.4
Single marker	7	14.1	5.5-31.5	Q = 1.806, P = 0.179
Antibody assay
Wantai assay	8	28.4	21.4-36.6
Other assays	6	12.3	7.7-19.1	Q = 10.134, P = 0.001b
Follow-up
≤ 12 mo	7	23.8	23.8
> 12 mo	4	26.8	26.8	Q = 0.072, P = 0.789

^bP < 0.01.

^cP < 0.001. CI: Confidence interval; n: Number of studies.