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©The Author(s) 2021.
World J Gastroenterol. Mar 28, 2021; 27(12): 1194-1212
Published online Mar 28, 2021. doi: 10.3748/wjg.v27.i12.1194
Published online Mar 28, 2021. doi: 10.3748/wjg.v27.i12.1194
Table 3 Previous studies examining the efficacy of cytapheresis in refractory ulcerative colitis
Ref. | Refractory type | Number of patients | Evaluation items1 | Rate of remission (evaluation time) | Rate of steroid- free remission (evaluation time) |
Naganuma et al[44] (2004) | SR | 10 | Induction | Severe 20%, moderate 70% | |
Giampaolo et al[45] (2006) | SR | 8 | Induction, sustained remission | 100% | 100%, 12.5% (12 mo) |
Ricart et al[46] (2007) | SD | 20 | Induction, sustained remission | 42.1% (17 wk) | 36.8% (17 wk), 85.7% (12 mo) |
Cabriada et al[47] (2010) | SD | 18 | Induction, sustained remission | 55% (1 mo), 75% (12 mo) | |
Cabriada et al[48] (2012) | SD | 142 | Induction, sustained remission | 37% (1 mo), 51%2 (12 mo) | |
Sacco et al[49] (2013) | SD + SR | 83 (SD 55, SR 28) | Induction, sustained remission | 71%, 48% (12 mo) | |
Yokoyama et al[43] (2014) | SD + SR | 401 (SD 229, SR 172) | Induction | SD: 64.6% (2 wk), SR: 70.9 (2 wk) | |
Dignass et al[50] (2016) | SD | 86 | Induction | 39.3% (12 wk) | 22.6% (12 wk) |
Imperiali et al[51] (2017) | SD | 33 | Induction | 36% (12 mo) | |
Dignass et al[52] (2018) | SD | 95 | Induction | 34.0% (24 wk), 33.0% (48 wk) | 19.2% (24 wk), 19.2% (48 wk) |
Domènech et al[53] (2018) | SD | 63 | Induction | 13% (24 wk) | |
Present study | SD + SR | 55 (SD 33, SR 21) | Induction, sustained remission | SD: 69.7% (4 wk), SR: 66.7% (4 wk) | SD: 42.4% (4 wk) SR: 47.6% (4 wk); SD: 69.2% (12 mo), SR: 63.6% (12mo) |
- Citation: Iizuka M, Etou T, Shimodaira Y, Hatakeyama T, Sagara S. Cytapheresis re-induces high-rate steroid-free remission in patients with steroid-dependent and steroid-refractory ulcerative colitis. World J Gastroenterol 2021; 27(12): 1194-1212
- URL: https://www.wjgnet.com/1007-9327/full/v27/i12/1194.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i12.1194