Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation

Table 2 Univariate and multiple logistic regression analyses of perioperative data stratified by the severity of complications

Variables	mean ± SD or No (%)		P value	OR	95%CI	P value
	MiC, n = 109	MaC, n = 131
Male gender	54 (49.5)	52 (39.7)	0.081
Age (d)	632 ± 440	512 ± 490	< 0.001
Weight (kg)	9.67 ± 2.91	8.61 ± 3.09	< 0.001
Height (cm)	76.6 ± 11.2	71.9 ± 11.6	< 0.001
WAZ	-1.28 ± 1.24	-1.49 ± 1.31	0.105
HAZ	-0.28 ± 1.15	-0.54 ± 1.24	0.012
WHZ	-1.60 ± 1.34	-2.43 ± 1.48	< 0.001
BMIZ	-0.20 ± 1.11	-0.36 ± 1.39	0.001
Ascites	78 (71.6)	108 (82.4)	0.057
PELD score	16.2 ± 7.0	17.8 ± 8.2	0.14
Kasai surgery	50 (45.9)	61 (46.6)	0.698
Portal hypertension	97 (88.9)	131 (100.0)	0.132
Hepatopulmonary syndrome	16 (14.7)	15 (11.5)	0.414
Infections 30 d pre-LT	0.4 ± 0.6	0.6 ± 0.7	0.081
eGFR (mL/min/1.73 m2)1	228 ± 121	187 ± 104	0.006
Hemoglobin (g/dL)2	10.2 ± 1.5	9.3 ± 1.5	< 0.001
Platelets (× 103/mm3)2	196 ± 112	193 ± 118	0.789
INR2	1.24 ± 0.25	1.49 ± 0.56	< 0.001
Sodium (mEq/L)2	137 ± 2.7	135 ± 4.3	< 0.001
Potassium (mEq/L)2	4.4 ± 0.5	4.3 ± 0.7	0.613
Glucose (mEq/L)2	104 ± 59	92 ± 60	0.313
Albumin (g/dL)2	2.9 ± 0.9	2.5 ± 0.8	0.002
Total Bilirubin (g/dL)2	11.9 ± 7.3	13.4 ± 8.8	0.304
GBWR (%)	3.3 ± 1.1	3.7 ± 1.2	0.035
RBC (mL/kg)3	31.1 ± 25.4	46.7 ± 39.7	< 0.001	1.018	1.007-1.028	0.001
FFP (mL/kg)3	0.3 ± 2.6	3.0 ± 11.5	0.015
Platelets (mL/kg)3	0.1 ± 0.8	1.2 ± 6.0	0.021
Cryoprecipitate (mL/kg)3	0.0 ± 0.0	0.1 ± 1.2	0.196

¹Estimated glomerular filtration rate by simplified Schwartz's formula.

²Blood samples collected up to 72 h before liver transplantation (LT) anesthetic induction.

³Blood samples collected up to 2 h after the onset of LT anesthetic induction.

SD: Standard deviation; MiC: Minor complications group (I-IIIa); MaC: Major complications group (IIIb-V); WAZ: Weight-for-age z-score; HAZ: Height-for-age z-score; WHZ: Weight-for-height z-score; BMIZ: Body-mass-index-for-age z-score; PELD: Pediatric end-stage liver disease; LT: Liver transplantation; INR: International normalization ratio; GBWR: Graft-to-body-weight ratio; RBC: Red blood cells; FFP: Fresh frozen plasma; eGFR: Estimated glomerular filtration rate.