Long-term follow-up of cumulative incidence of hepatocellular carcinoma in hepatitis B virus patients without antiviral therapy

doi:10.3748/wjg.v27.i11.1101

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Mar 21, 2021 (publication date) through Dec 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Trials Study

World J Gastroenterol. Mar 21, 2021; 27(11): 1101-1116
Published online Mar 21, 2021. doi: 10.3748/wjg.v27.i11.1101

Table 1 Data regarding the patients’ baseline characteristics

	Chronic hepatitis B patients		Hepatitis B cirrhosis patients
	Observation group (n = 362)	Control group (n = 203)	Observation group (n = 96)	Control group (n = 129)
Sex: Males (%)	291 (80.38)	175 (86.20)^a	74 (77.08)	119 (92.24)^a
E antigen-positive patients (%)	198 (54.69)	123 (60.59)^a	30 (31.25)	32 (24.80)
Age (yr)	33 (25-40)	39 (32-46)^a	59.50 (48-67)	48 (41-58)
Median follow-up time	10 (7-14)	8 (6-9)^a	7 (5-8)	7 (6-8)
HBV-DNA (log)	7.14 (5.92-7.70)	6.76 (5.63-7.29)	4.77 (4.37-5.53)	4.92 (4.06-5.57)
ALT	188.62 (141.70-296.55)	185.50 (135.01-260.25)	98.73 (75.91-121.73)	110.00 (78.10-202.00)
AST	132.14 (100.00-173.57)	135.00 (110.00-215.00)	53.15 (40.77-122.58)	76.00 (49.00-105.00)
TB	27.00 (21.30-36.50)	28.50 (21.00-41.25)	39.10 (33.00-45.00)	37.00 (18.00-51.00)^a
ALB			32.00 (26.00-37.70)	36.00 (33.50-37.00)
PLT			99.50 (58.00-120.00)	107.00 (102.00-119.00)^a
Diabetes (%)	39 (10.77)	21 (10.34)	21 (21.87)	26 (20.15)
Hypertension (%)	29 (8.01)	18 (8.86)	23 (23.95)	25 (19.37)
Family history of hepatocellular carcinoma (%)	21 (5.80)	10 (4.97)	19 (19.76)	27 (20.93)
REACH-B score	10 (8-12)	10 (8-12)

^aP < 0.05 compared with the observation group. HBV: Hepatitis B virus; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TB: Total bilirubin; ALB: Albumin; PLT: Platelet.

Citation: Jiang XY, Huang B, Huang DP, Wei CS, Zhong WC, Peng DT, Huang FR, Tong GD. Long-term follow-up of cumulative incidence of hepatocellular carcinoma in hepatitis B virus patients without antiviral therapy. World J Gastroenterol 2021; 27(11): 1101-1116
URL: https://www.wjgnet.com/1007-9327/full/v27/i11/1101.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i11.1101