Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

doi:10.3748/wjg.v27.i11.1064

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2021; 27(11): 1064-1075
Published online Mar 21, 2021. doi: 10.3748/wjg.v27.i11.1064

Table 4 Association of the models for end-stage liver disease score and variables in pre-orthotopic liver transplantation patients according to E2, E3 and E4 allele stratification

Variables	MELD≤ 25				MELD> 25				MELD≤ 25			MELD> 25
	*APOE*2	*APOE*3	*APOE*4		*APOE*2	*APOE*3	*APOE*4		*APOE4*			*APOE*4
	*APOE*2	*APOE*3	*APOE*4		*APOE*2	*APOE*3	*APOE*4		(Yes)	(No)		(Yes)	(No)
	n²(%)	n²(%)	n²(%)	P value	n²(%)	n²(%)	n²(%)	P value	n²(%)	n²(%)	P value	n²(%)	n²(%)	P value
METAVIR (n¹= 38; n²= 76)
A1F4 (n¹= 27; n²= 54)	9 (20.4)	27 (61.4)³	8 (18.2)	0.085	4 (40.0)	4 (40.0)	2 (20.0)	NA	8 (18.2)	36 (81.8)	0.044^a	2 (20.0)	4 (80.0)	NA
A3F4 (n¹= 11; n²= 22)	4 (18.2)	18 (81.8)	0 (0.0)³	0.085	0 (0.0)	0 (0.0)	0 (0.0)	NA	0 (0.0)	22 (100.0)	0.044^a	0 (0.0)	0 (0.0)	NA
METAVIR (n¹= 91; n²= 182)
≤ A2F4 (n¹= 80; n²= 160)	26 (18.6)	92 (65.7)⁴	22 (15.7)	0.123	5 (25.0)	11 (55.0)	4 (20.0)	NA	22 (15.7)	118 (84.3)	0.046^a	4 (20.0)	16 (80.0)	NA
A3F4 (n¹= 11; n²= 22)	4 (18.2)	18 (81.8)	0 (0.0)⁴	0.123	0 (0.0)	0 (0.0)	0 (0.0)	NA	0 (0.0)	22 (100.0)	0.046^a	0 (0.0)	0 (0.0)	NA

n¹: Number of subjects; n²: Number of alleles.

³APOE3 vs APOE4 allele frequency, P = 0.040.

⁴APOE3 vs APOE4 allele frequency, P = 0.042.

^aP < 0.05. METAVIR F4: Cirrhosis; METAVIR A1: Minimal degree of inflammation; METAVIR A1A2: Minimal and moderate degree of inflammation; METAVIR A3: High degree of inflammation; APOE: Apolipoprotein E gene; MELD: Model for end-stage liver disease; NA: Not applicable.

Citation: Nascimento JCR, Pereira LC, Rêgo JMC, Dias RP, Silva PGB, Sobrinho SAC, Coelho GR, Brasil IRC, Oliveira-Filho EF, Owen JS, Toniutto P, Oriá RB. Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis. World J Gastroenterol 2021; 27(11): 1064-1075
URL: https://www.wjgnet.com/1007-9327/full/v27/i11/1064.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i11.1064