Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

doi:10.3748/wjg.v27.i11.1064

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2021; 27(11): 1064-1075
Published online Mar 21, 2021. doi: 10.3748/wjg.v27.i11.1064

Table 2 Genotypic and allele distribution of apolipoprotein E according to group, hepatitis C virus serology/viral load and severity of liver inflammation by the METAVIR score of the total population

*APOE* genotype		Group		HCV-RNA		METAVIR		METAVIR
	All	HCV	HCV + HCC	Positive	Negative	≤ A2F4	A3F4	A1F4	A3F4
	n¹ (179)	n¹(74)	n¹(105)	n¹(33)	n¹(146)	n¹(80)	n¹(11)	n¹(27)	n¹(11)
E2/E2	15 (8.4)	6 (8.1)	9 (8.6)	7 (21.2)	8 (5.5)	9 (11.2)	1 (9.1)	4 (14.8)	1 (9.1)
E2/E3	25 (14.0)	9 (12.2)	16 (15.2)	3 (9.1)	22 (15.1)	11 (13.8)	2 (18.2)	4 (14.8)	2 (18.2)
E2/E4	6 (3.3)	3 (4.1)	3 (2.9)	0 (0.0)	6 (4.1)	2 (2.5)	0 (0.0)	1 (3.7)	0 (0.0)
E3/E3	92 (51.4)	36 (48.6)	56 (53.3)	16 (48.5)	76 (52.0)	39 (48.8)	8 (72.7)	12 (44.5)	8 (72.7)
E3/E4	32 (17.9)	15 (20.3)	17 (16.2)	5 (15.1)	27 (18.5)	14 (17.5)	0 (0.0)	3 (11.1)	0 (0.0)
E4/E4	9 (5.0)	5 (6.7)	4 (3.8)	2 (6.1)	7 (4.8)	5 (6.2)	0 (0.0)	3 (11.1)	0 (0.0)
*APOE* alleles	n²(%)	n²(%)	n²(%)	n²(%)	n²(%)	n²(%)	n²(%)	n²(%)	n²(%)
E2	61 (17.1)	24 (16.2)	37 (17.6)	17 (25.8)	44 (15.1)	31 (19.4)	4 (18.2)	13 (24.1)	4 (18.2)
E3	241 (67.3)	96 (64.9)	145 (69.1)	40 (60.6)	201 (68.8)	103 (64.4)	18 (81.8)	31 (57.4)	18 (81.8)
E4	56 (15.6)	28 (18.9)	28 (13.3)	9 (13.6)	47 (16.1)	26 (16.2)	0(0.0)	10 (18.5)	0 (0.0)
All	358	148	210	66	292	160	22	54	22

METAVIR score of biopsies liver explants from 89 patients and from 2 patients in pre-transplant. n¹: Number of subjects; n²: Number of alleles; APOE: Apolipoprotein E gene; HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma.

Citation: Nascimento JCR, Pereira LC, Rêgo JMC, Dias RP, Silva PGB, Sobrinho SAC, Coelho GR, Brasil IRC, Oliveira-Filho EF, Owen JS, Toniutto P, Oriá RB. Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis. World J Gastroenterol 2021; 27(11): 1064-1075
URL: https://www.wjgnet.com/1007-9327/full/v27/i11/1064.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i11.1064