Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

doi:10.3748/wjg.v27.i11.1064

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2021; 27(11): 1064-1075
Published online Mar 21, 2021. doi: 10.3748/wjg.v27.i11.1064

Table 1 Demographic and clinical profile of all candidate patients for liver transplant according to E2, E3 and E4 allele stratification

Variables	*APOE*2	*APOE*3	*APOE*4	P value
Age (yr) (mean ± SD)	60.8 ± 7.26	60.3 ± 7.19	60.3 ± 7.44	0.956
BMI (mean ± SD)	27.6 ± 4.36	26.4 ± 5.01	27.0 ± 4.81	0.167
Gender (n¹= 179; n²= 358), n²(%)
Male (n¹= 145; n²= 290)	52 (17.9)	193 (66.6)	45 (15.5)	0.650
Female (n¹= 34; n²= 68)	9 (13.2)	48 (70.6)	11 (16.2)	0.650
BMI (n¹= 179; n²= 358), n²(%)
Non-obese (n¹= 137; n²= 274)	49 (17.9)	185 (67.5)	40 (14.6)	0.519
Obese (n¹= 42; n²= 84)	12 (14.3)	56 (66.7)	16 (19.0)	0.519
Etiology (n¹= 179; n²= 358), n²(%)
HCV (n¹= 74; n²= 148)	24 (16.2)	96 (64.9)	28 (18.9)	0.357
HCV + HCC (n¹= 105; n²= 210)	37 (17.6)	145 (69.0)	28 (13.3)	0.357
HCC Milan (n¹= 105; n²= 210), n²(%)
Within the criteria (n¹= 83; n²= 166)	29 (17.5)	115 (69.3)	22 (13.2)	0.885
Outside the criteria (n¹= 22; n²= 44)	8 (18.2)	29 (65.9)	7 (15.9)	0.885

Of 105 patients complicated with hepatocellular carcinoma. n¹: Number of subjects; n²: Number of alleles; APOE: Apolipoprotein E gene; BMI: Body mass index; HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma.

Citation: Nascimento JCR, Pereira LC, Rêgo JMC, Dias RP, Silva PGB, Sobrinho SAC, Coelho GR, Brasil IRC, Oliveira-Filho EF, Owen JS, Toniutto P, Oriá RB. Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis. World J Gastroenterol 2021; 27(11): 1064-1075
URL: https://www.wjgnet.com/1007-9327/full/v27/i11/1064.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i11.1064