Copyright
©The Author(s) 2021.
World J Gastroenterol. Mar 14, 2021; 27(10): 919-927
Published online Mar 14, 2021. doi: 10.3748/wjg.v27.i10.919
Published online Mar 14, 2021. doi: 10.3748/wjg.v27.i10.919
NCT number | Institution | Disease | Estimated enrollment | Phase | Primary endpoint | Intervention |
NCT04167293 | China (Sun Yat-sen University Cancer Center) | HCC with portal vein invasion | 116 | II/III | 6-mo PFS | SBRT + sintilimab vs SBRT |
NCT03817736 | Hong Kong (Queen Mary Hospital) | HCC | 33 | II | Number of patients eligible for curative surgical interventions | TACE/SBRT + ICI |
NCT03203304 | United States (University of Chicago) | Unresectable HCC | 50 | I | Number of participants with adverse events | Nivolumab + SBRT vs nivolumab and ipilimumab + SBRT |
NCT04611165 | South Korea (NCC) | HCC with major vascular invasion | 50 | II | PFS | Nivolumab + EBRT |
NCT03482102 | United States (MGH) | Locally advanced/unresectable or metastatic HCC or biliary tract cancer | 70 | II | ORR | Tremelimumab + durvalumab + RT |
NCT03316872 | Canada (UHN) | HCC progression after sorafenib | 30 | II | ORR | Pembrolizumab + SBRT |
NCT04547452 | China (West China Hospital) | Metastatic HCC | 84 | II | PFS | SBRT + sintilimab vs sintilimab |
NCT04193696 | China (Guangxi Medical University) | Advanced HCC | 39 | II | ORR | RT+ anti-PD-1 agent |
- Citation: Lee BM, Seong J. Radiotherapy as an immune checkpoint blockade combination strategy for hepatocellular carcinoma. World J Gastroenterol 2021; 27(10): 919-927
- URL: https://www.wjgnet.com/1007-9327/full/v27/i10/919.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i10.919