Valuable clinical indicators for identifying infantile-onset inflammatory bowel disease patients with monogenic diseases

Table 3 Results of blood test and inflammatory factors among three groups of patients (median, interquartile range)

	AP	M-IBD	NM-IBD	P value
WBC (× 109)	8.77 (6.78, 10.75)1	14.88 (9.84, 19.37)	13.77 (8.87,18.51)	< 0.001
Hemoglobin (mg/L)	119 (115, 126)1	98 (90, 113)	100 (80.50,116)	< 0.001
PLT (× 109)	304 (254, 383)1	447 (306.75, 591.50)	477 (323.50, 601.50)	0.002
CRP (mg/L)	1 (0.20, 1.00)1	48 (7.98, 75.23)1	21 (1.00, 44.35)	< 0.001
ESR (mm/h)	6 (4, 8)1	18.50 (8, 39)	21 (6, 42)	< 0.001
TNF-α (pg/mL)	14.60 (10.68, 17.03)1	21.50 (17.58, 27.88)	22.90 (14.48, 61.28)	< 0.001
IL-6 (pg/mL)	2.85 (2.00, 3.35)1	21.00 (10.20, 50.30)	14.55 (6.81, 30.00)	< 0.001
IL-10 (pg/mL)	500 (5, 5)	85.50 (42.75, 127.25)1	6.37 (5.00, 14.80)	< 0.001
Ferritin (ng/mL)	22.90 (14.90, 37.05)	55.90 (36.10, 231.20)1	15.50 (10.60, 27.72)	< 0.001
Albumin (g/L)	41 (38, 43)1	31 (27, 35)	33 (27.00, 36.50)	< 0.001
Serum iron (μmol/L)	8.00 (5.90, 10.20)	3.90 (2.60, 6.88)	5.70 (4.35, 11.38)	0.069

¹Compared with the other two groups, adjusted P value < 0.05. AP: Allergic proctocolitis; M-IBD: Monogenic inflammatory bowel disease; NM-IBD: Non-monogenic inflammatory bowel disease; WBC: White blood cells; PLT: Platelets; CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate; TNF: Tumor necrosis factor; IL: Interleukin.