Valuable clinical indicators for identifying infantile-onset inflammatory bowel disease patients with monogenic diseases

Table 2 Clinical features and growth parameters among three groups of patients

	AP	M-IBD	NM-IBD	P value
Total number	40	44	29
Male (%)	25 (62.50)	27 (61.36)	21 (72.41)	0.591
Median onset age (mo, IQR)	4.44 (1.25,11.76)	0.51 (0.04,1.79)1	3.99 (3.00,9.00)	< 0.001
Diarrhea (≥ 8 times/d, %)	10 (25.00) 1	38 (86.40) 1	17 (58.60)	< 0.001
Diarrhea with blood (%)	30 (75.00)	29 (65.90)	24 (82.80)	0.320
Perianal disease (%)	0 (0)	35 (79.54) 1	7 (24.14)	0.005
Fever (%)	2 (5.00)1	28 (63.63)	12 (41.38)	< 0.001
Death (%)	0 (0.00)	9 (20.45)	1 (3.45)2	0.001
Z scores for weight (mean ± SD)	-0.05 ± 0.211	-1.95 ± 0.26	-1.15 ± 0.29	< 0.001
Z scores for height (mean ± SD)	0.19 ± 0.191	-1.95 ± 0.25	-1.32 ± 0.31	< 0.001
Z scores for BMI (mean ± SD)	-0.21 ± 0.242	-1.30 ± 0.28	-0.52 ± 0.27	0.026

¹Compared with the other two groups, adjusted P value < 0.05.

²Compared with the monogenic inflammatory bowel disease (M-IBD) group, adjusted P value < 0.05. AP: Allergic proctocolitis; M-IBD: Monogenic inflammatory bowel disease; NM-IBD: Non-monogenic inflammatory bowel disease; IQR: Interquartile range; SD: Standard deviation; BMI: Body mass index.