Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice

Figure 3 Regulation of KMO is involved in induction of Foxp3⁺ Treg cells. A: Serial sections of the colons of the indicated mice were stained for Foxp3 and counterstained with hematoxylin. B–E: CD4⁺Foxp3⁺ cells and CD11c⁺CD103⁺ cells were analyzed using flow cytometry on colonic LP cells and MLN cells, respectively, from indicated mice, gated on 7-AAD^-CD45.2⁺ cells. Representative flow cytometry plots and cumulative datagraphical summary are depicted. Data are representative of at least five independent experiments with similar results: ^aP < 0.05 vs TNBS-treated KMO^+/+ mice group; ^cP < 0.05 vs KMO^−/− Vehicle group. KMO: Kynurenine 3-monooxygenase; TNBS: Trinitrobenzene sulfonic acid.