Magnetic resonance imaging biomarkers for pulsed focused ultrasound treatment of pancreatic ductal adenocarcinoma

Figure 3 Histochemical and biochemical parameter changes due to pulsed focused ultrasound treatments. A: Hyaluronic acid (HA) and sulfated glycosaminoglycan concentrations in treated and sham treated KPC and orthotopic mice; B: HA intensities in treated and non-treated regions of the tumor in KPC, orthotopic, and subcutaneous models; C: Representative histological image of HA binding protein stained section for a KPC mouse. The treated region is outline by a dashed line. KPC: Genetic mouse model; Ortho: Orthotopic; HA: Hyaluronic acid.