Downregulation of orosomucoid 2 acts as a prognostic factor associated with cancer-promoting pathways in liver cancer

Figure 5 Gene enrichment analysis shows ORM2 downregulation is closely associated with cancer-promoting pathways. A: Heatmap of the top 50 features for each phenotype in single ORM2 gene enrichment analysis in The Cancer Genome Atlas (TCGA) liver cancer database. B-F: Gene set enrichment analysis (GSEA) of ORM2 genes in the TCGA liver cancer database with the Hallmarks module. Enrichment signaling pathways are shown as G2/M checkpoint, E2F target signaling, mitotic spindle, Wnt/β-catenin and hedgehog signaling. G: Leading edges analysis of GSEA evaluations was performed on the ORM2 gene. I: G2/M checkpoint, II: E2F target signaling, III: Mitotic spindle, IV: Wnt/β-catenin signaling, V: Hedgehog signaling pathway.