Neoadjuvant chemotherapy vs upfront surgery for gastric signet ring cell carcinoma: A retrospective, propensity score-matched study

Table 4 Comparison of operative and postoperative parameters between neoadjuvant chemotherapy and surgery-first groups, n (%)

Variable	All patients		P value	Matched patients		P value
	NAC and surgery (n = 36)	Surgery first (n = 108)		NAC and surgery (n = 36)	Surgery first (n = 36)
Type of surgery			0.109			0.430
Total gastrectomy	24 (66.7)	87 (80.6)		24 (66.7)	28 (77.8)
Subtotal gastrectomy	12 (33.3)	21 (19.4)		12 (33.3)	8 (22.2)
Combined resection			1.000			1.000
Yes	1 (2.8)	4 (3.7)		1 (2.8)	2 (5.6)
No	35 (97.2)	104 (96.3)		35 (97.2)	34 (94.4)
Resection			1.000			1.000
R0	32 (88.9)	96 (88.9)		32 (88.9)	31 (86.1)
R1/R2	4 (11.1)	12 (11.1)		4 (11.1)	5 (13.9)
Operation time (min)	196 ± 54	197 ± 56	0.961	196 ± 54	190 ± 49	0.600
Blood loss (mL)	144 ± 139	127 ± 140	0.527	144 ± 139	129 ± 122	0.628
Blood transfusion			0.495			1.000
Yes	32 (88.9)	100 (92.6)		4 (11.1)	4 (11.1)
No	4 (11.1)	8 (7.4)		32 (88.9)	32 (88.9)
Morbidity			0.563			0.478
Yes	3 (8.3)	14 (13.0)		3 (8.3)	6 (16.7)
No	33 (91.7)	94 (87.0)		33 (91.7)	30 (83.3)
Postoperative hospital stay (d)	13.3 ± 4.9	13.9 ± 13.2	0.821	13.3 ± 4.9	14.2 ± 14.0	0.743
Borrmann type			0.082			0.450
I	3 (8.3)	10 (9.3)		3 (8.3)	1 (2.8)
II	10 (27.8)	11 (10.2)		10 (27.8)	6 (16.7)
III	17 (47.2)	69 (63.9)		17 (47.2)	22 (61.1)
IV	6 (16.7)	18 (16.7)		6 (16.7)	7 (19.4)
Tumor size (cm)	5.9 ± 3.3	5.9 ± 2.9	0.995	5.9 ± 3.2	6.0 ± 3.5	0.927
Neural invasion			0.700			0.474
Yes	18 (50.0)	74 (68.5)		17 (47.2)	13 (36.1)
No	18 (50.0)	34 (31.5)		19 (52.8)	23 (63.9)
Lymphovascular invasion			0.848			0.341
Yes	17 (47.2)	55 (50.9)		18 (50.0)	23 (63.9)
No	19 (52.8)	53 (49.1)		18 (50.0)	13 (36.1)
Pathological tumor classification			0.001			0.039
(y)pT0-1	5 (13.9)	0 (0)		5 (13.9)	0 (0)
(y)pT2	0 (0)	1 (0.9)		0 (0)	1 (2.8)
(y)pT3	9 (25.0)	40 (37.0)		9 (25.0)	15 (41.7)
(y)pT4a/4b	22 (61.1)	67 (62.0)		22 (61.1)	20 (55.6)
Pathologic nodal classification			0.09			0.671
(y)pN0	12 (34.3)	15 (13.9)		12 (34.3)	8 (22.2)
(y)pN1	3 (8.6)	12 (11.1)		3 (8.6)	3 (8.3)
(y)pN2	7 (20.0)	28 (25.9)		7 (20.0)	7 (19.4)
(y)pN3	13 (37.1)	53 (49.1)		13 (37.1)	18 (50.0)
Adjuvant chemotherapy			1.000			0.396
Yes	26 (72.2)	77 (71.3)		26 (72.2)	30 (83.3)
No	10 (27.8)	31 (28.7)		10 (27.8)	6 (16.7)

NAC: Neoadjuvant chemotherapy.