Promising key genes associated with tumor microenvironments and prognosis of hepatocellular carcinoma

Table 3 Univariate and multivariate Cox regression analyese of prognostic factors and overall survival of patients with hepatocellular carcinoma from The Cancer Genome Atlas database

Variable	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Risk score	11.37	5.49-23.56	< 0.001	8.99	2.53-32.01	0.001
TNM stage	1.79	1.45-2.22	< 0.001	1.24	0.89-1.75	0.209
Age	1.01	0.99-1.02	0.254
Gender	0.79	0.55-1.13	0.192
Race	1.13	0.94-1.37	0.196
Child-Pugh score	1.69	0.93-3.07	0.084
ECGO performance status	2.41	1.91-3.04	< 0.001	1.74	1.16-2.63	0.008
AFP	1	1-1	0.443
Fibrosis ishak score	0.91	0.78-1.07	0.253
Histologic grade	1.1	0.86-1.4	0.445
Vascular invasion	1.47	1.06-2.06	0.022	1.16	0.75-1.79	0.511
Hepatitis virus infection	0.45	0.3-0.68	< 0.001	0.81	0.45-1.46	0.477
Alcohol consumption	1.1	0.75-1.62	0.616

HR: Hazard ratio; CI: Confidential interval; ECOG: Eastern Cooperative Oncology Group.