Promising key genes associated with tumor microenvironments and prognosis of hepatocellular carcinoma

doi:10.3748/wjg.v26.i8.789

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Feb 28, 2020 (publication date) through Feb 7, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2020; 26(8): 789-803
Published online Feb 28, 2020. doi: 10.3748/wjg.v26.i8.789

Table 2 Top 10 genes predicting overall survival screened by lasso regression in hepatocellular carcinoma cohort from The Cancer Genome Atlas

Gene	Univariate Cox regression analysis			LASSO coefficient
Gene	HR	95%CI	P value	LASSO coefficient
NLRC3	0.72	0.60-0.87	0.0008	-0.0780
CFHR3	0.89	0.84-0.94	0.0001	-0.0375
KLRB1	0.84	0.76-0.93	0.0008	-0.0276
CTSL2	1.13	1.05-1.21	0.0005	0.0173
ADH1C	0.91	0.87-0.96	0.0002	-0.0149
CD5L	0.90	0.85-0.95	0.0004	-0.0131
TMC5	1.06	1.01-1.12	0.0255	0.0106
DOK5	0.84	0.75-0.95	0.0041	-0.0082
UGT2B15	0.91	0.86-0.96	0.0007	-0.0072
RASGRP2	0.82	0.72-0.93	0.0016	-0.0062

HR: Hazard ratio; CI: Confidential interval.

Citation: Pan L, Fang J, Chen MY, Zhai ST, Zhang B, Jiang ZY, Juengpanich S, Wang YF, Cai XJ. Promising key genes associated with tumor microenvironments and prognosis of hepatocellular carcinoma. World J Gastroenterol 2020; 26(8): 789-803
URL: https://www.wjgnet.com/1007-9327/full/v26/i8/789.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i8.789