Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery

Table 7 Preoperative liver function parameters in post-hepatectomy liver failure and non-post-hepatectomy liver failure patients who did not have hepatitis viruses in univariate analysis

Factors	No postoperative liver failure	Postoperative liver failure	Univariate analysis
	(n = 136)	(n = 22)	OR (95%CI)	P value
Age, yr (mean)	65.3	70.7		0.09
Sex, male/female	87/49	4/18		0.109
Preoperative biliary drainage	9	4		0.045
Child-Pugh score	5.15 ± 0.39	5.59 ± 0.80	3.694 (1.766-7.729)	0.001
Platelets (× 104/μL)	21.1 ± 7.7	17.1 ± 7.0		0.991
Total bilirubin (mg/dL)	0.79 ± 0.33	0.91 ± 0.40		0.111
PT-INR (INR)	0.99 ± 0.13	1.1 ± 0.14	123.581 (2.637-5791.435)	0.014
Albumin (g/dL)	4.03 ± 0.44	3.57 ± 0.60	0.157 (0.059-0.414)	< 0.001
Aspartate aminotransferase (IU/L)	30.8 ± 26.6	41.5 ± 25.9		0.121
Alanine aminotransferase (IU/L)	28.0 ± 22.9	33.6 ± 25.5		0.296
Cholinesterase (IU/L)	293.1 ± 85.1	192.2 ± 67.9	0.979 (0.970-0.988)	< 0.001
Total cholesterol (mg/dL)	192.2 ± 42.2	168.4 ± 40.2	0.985 (0.973-0.998)	0.02
ICG-15 clearance rate (%)	10.3 ± 9.11	15.0 ± 11.8	1.034 (0.998-1.081)	0.064
Type IV collagen 7S (ng/mL)	5.36 ± 1.85	9.15 ± 3.13	1.731 (1.383-2.167)	< 0.001
Hyaluronic acid (ng/mL)	78.7 ± 99.2	261.9 ± 207.3	1.005 (1.004-1.011)	< 0.001
ARFITM (v/s)	1.49 ± 0.53	1.98 ± 0.67	2.785 (1.546-7.887)	0.003
CRP (mg/dL)	0.47 ± 1.14	1.00 ± 1.42		0.056
Extent of hepatic resection[26]	0.90 ± 1.0	1.41 ± 1.05	1.638 (1.037-2.587)	0.034

PT-INR: Prothrombin time-international normalized ratio; ICG-R15: Indocyanine green retention rate at 15 min; ARFI: Acoustic radiation force impulse; CRP: C-reactive protein.