Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery

Table 2 Preoperative levels of liver function parameters in patients with and without postoperative liver failure in univariate analysis

Factor	No postoperative liver failure	Postoperative liver failure	Univariate analysis
	(n = 188)	(n = 27)	OR (95%CI)	P value
Age, yr (median)	68	72		0.095
Sex, male/female	125/63	4/23		0.064
Preoperative biliary drainage	15	7		0.005
Child-Pugh score	5.16 ± 0.45	5.48 ± 0.75	2.505 (1.345-4.665)	0.004
Blood platelet (× 104/μL)	19.5 ± 7.7	16.7 ± 6.6		0.099
Total bilirubin (mg/dL)	0.80 ± 0.33	0.90 ± 0.39		0.099
PT-INR (INR)	1.00 ± 0.12	1.09 ± 0.13	63.56 (2.533-1595.002)	0.012
Albumin (g/dL)	4.03 ± 0.45	3.64 ± 0.54	0.210 (0.091-0.484)	< 0.001
Aspartate aminotransferase (IU/L)	30.9 ± 23.6	40.6 ± 24.8	1.012 (0.999-1.025)	0.071
Alanine aminotransferase (IU/L)	27.3 ± 20.7	32.6 ± 24.2		0.171
Cholinesterase (IU/L)	284.2 ± 82.1	194.6 ± 69.9	0.982 (0.975-0.990)	< 0.001
Total cholesterol (mg/dL)	188.2 ± 39.2	165.8 ± 37.1	0.984 (0.972-0.996)	0.011
ICG-R15 (%)	10.9 ± 9.01	14.8 ± 11.1	1.034 (0.998-1.071)	0.068
Type IV collagen 7S (ng/mL)	5.50 ± 1.91	8.80 ± 3.06	1.601 (1.340-1.914)	< 0.001
Hyaluronic acid (ng/mL)	88.5 ± 100.6	256.5 ± 216.5	1.005 (1.001-1.009)	0.018
ARFITM (v/s)	1.56 ± 0.57	2.01 ± 0.69	2.785 (1.431-5.422)	0.003
CRP (mg/dL)	0.39 ± 1.01	0.82 ± 1.33	1.319 (0.995-1.747)	0.054
Extent of hepatic resection[26]	0.81 ± 0.97	1.37 ± 1.04	1.688 (1.114-2.557)	0.013

PT-INR: Prothrombin time-international normalized ratio; ICG-R15: Indocyanine green retention rate at 15 min; ARFI: Acoustic radiation force impulse; CRP: C-reactive protein.