Validation and evaluation of clinical prediction systems for first and repeated transarterial chemoembolization in unresectable hepatocellular carcinoma: A Chinese multicenter retrospective study

Table 4 Comparison of prognostic performance of the predicting systems

Predicting systems	Candidates/non-candidates		Predicting performance
	Number of patients	Median survival (mo)	Cox Regression		C-index (95%CI)	LRχ2
			HR (95%CI)	P value
For first TACE
HAP	465/642	33.8/19.3	0.56 (0.47-0.67)	< 0.001	0.59 (0.56-0.61)	43.71
mHAP	673/434	30.8/16.1	0.58 (0.49-0.68)	< 0.001	0.59 (0.56-0.61)	40.85
mHAP 2	632/475	30.8/17.2	0.60 (0.51-0.71)	< 0.001	0.58 (0.56-0.60)	35.24
mHAP 3	554/553	33.8/17.2	0.52 (0.44-0.62)	< 0.001	0.60 (0.57-0.62)	57.51
6&12	562/545	31.3/18.5	0.61 (0.51-0.72)	< 0.001	0.58 (0.56-0.60)	33.82
For re-TACE
ART	646/266	27.0/23.7	0.88 (0.72-1.08)	0.226	0.52 (0.49-0.54)	1.56
ABCR	600/312	33.1/16.4	0.47 (0.39-0.57)	< 0.001	0.61 (0.59-0.63)	57.36

TACE: Transarterial chemoembolization; HR: Hazard ratio; CI: Confidence interval; LR: Likelihood ratio; HAP: Hepatoma Arterial-embolization Prognostic; mHAP: Modified HAP; 6&12: Six-and-twelve criteria; ART: Assessment for re-treatment with TACE; ABCR: Alpha-fetoprotein, BCLC stage, Child-Pugh and Response.