Characterizing the composition of intestinal microflora by 16S rRNA gene sequencing

Table 2 Statistics of alpha diversity

α	Normal mucosa	Advanced CRA	Adjacent normal mucosa	P value
Sobs	271 ± 90	215 ± 86	253 ± 91	< 0.001a
Chao	301 ± 102	249 ± 104	291 ± 95	0.008
ACE	296 ± 102	253 ± 105	291 ± 93	0.020
Shannon	2.56 ± 0.68	2.30 ± 0.71	2.68 ± 0.72	0.028
Simpson	0.21 ± 0.12	0.26 ± 0.11	0.20 ± 0.12	0.031

ACE: Index used to estimate the number of OTU in the community; CRA: Colorectal adenoma.

^aP < 0.001: P = 0.00076.