Upregulation of miR-34c after silencing E2F transcription factor 1 inhibits paclitaxel combined with cisplatin resistance in gastric cancer cells

Figure 4 microRNA-34c inhibits drug resistance and the activity of gastric cancer cells. A: miR-34c was underexpressed in GC tissues. ^eP < 0.001 vs adjacent normal tissues; B: miR-34c was underexpressed in cancer cells. ^aP < 0.05 and ^bP < 0.01 vs GES-1 cells; C: miR-34c inhibited cell activity. ^aP < 0.05 in multi-group comparisons; D: miR-34c inhibited cell resistance. ^bP < 0.01 vs the NC mimics group and ^cP < 0.05 vs the NC inhibitor group; E: miR-34c inhibited the expression of Bcl2 and promoted the expression levels of Caspase 9, Caspase 3 and Bax. ^aP < 0.05 vs the NC mimc group and ^cP < 0.05 vs the NC inhibitor group.