Upregulation of miR-34c after silencing E2F transcription factor 1 inhibits paclitaxel combined with cisplatin resistance in gastric cancer cells

Figure 3 E2F transcription factor 1 targeted inhibition of microRNA 34c transcription. A: There were binding sites in the promoter region between E2F1 and miR-34c; B: miR-34c presented low expression in GC cells. ^aP < 0.05 and ^bP < 0.01 vs GES-1; C: E2F1 might inhibit the expression of miR-34c. ^aP < 0.05, and ^dP < 0.01; D: Double luciferase reporter gene validated the targeting relationship between E2F1 and miR-34c. ^bP < 0.01 vs NC mimcs.