Upregulation of miR-34c after silencing E2F transcription factor 1 inhibits paclitaxel combined with cisplatin resistance in gastric cancer cells

Figure 1 E2F transcription factor 1 enhances cell activity and promotes the formation of drug resistance. A: E2F1 was highly expressed in GC tissues, ^eP < 0.001; B: E2F1 was highly expressed in GC cells. ^aP < 0.05, ^bP < 0.01, and ^eP < 0.001 when compared with GES-1; C: E2F1 enhanced cell activity, a indicated ^aP < 0.05 when compared between groups; D: E2F1 promoted cell resistance. ^eP < 0.001 vs the NC sh group, and ^dP < 0.01 vs the NC si group; E: E2F1 promoted the expression levels of MRP, MDR-1, Bcl2, and inhibited the expression levels of Caspase 9, Caspase 3, and Bax. ^aP < 0.05 vs the NC sh group, and ^cP < 0.05 vs the NC si group.