lncRNACNN3-206 activates intestinal epithelial cell apoptosis and invasion by sponging miR-212, an implication for Crohn's disease

Figure 6 Results of the mouse Crohn’s disease model. A: DAI scores of the five groups, including the TNBS model group (TNBS), lncRNACNN3-206 knockdown group (TBNS + anti-lncRNACNN3-206), and vector control group (TBNS + anti-scramble). The DAI scores after the 4^th wk of TNBS administration significantly decreased in the TBNS + anti-lncRNACNN3-206 group compared with the TBNS group. The DPI scores were similar in the TBNS and vector control groups; B: The TNBS and TNBS + anti-scramble groups were significantly shortened, and hyperemia was observed. However, no obvious contracture was observed in the colons from mice in the TNBS + si-lncRNACNN3-206 group. The ileocecal colon in this group had mild segmenting congestion, which was similar to that of the control group. ^aP < 0.05.