lncRNACNN3-206 activates intestinal epithelial cell apoptosis and invasion by sponging miR-212, an implication for Crohn's disease

Figure 5 Manipulation of lncRNACNN3-206 expression levels led to changes in cell function. A: Results of flow cytometry showed that overexpression or knockdown of lncRNACNN3-206 expression resulted in changes in Caco-2 (left) and HT-29 (right) cell apoptosis. The number of apoptotic cells in the lncRNACNN3-206 overexpression group (oe-lncRNACNN3-206) was significantly increased, while the number of apoptotic cells in the lncRNACNN3-206 knockdown group (si-lncRNACNN3-206) was significantly decreased, in comparison with the vector and blank control groups; B: Results of Trans-well invasion assays in Caco-2 (left) and HT-29 (right) cells. The number of invasive cells in the lncRNACNN3-206 overexpression (oe-lncRNACNN3-206) group was significantly increased, while the number of invasive cells in the lncRNACNN3-206 knockdown si-lncRNACNN3-206 group was significantly decreased, in comparison with the vector and blank control groups. ^aP < 0.05, ^bP < 0.01, ^eP < 0.001.