Prostate-specific membrane antigen expression in hepatocellular carcinoma, cholangiocarcinoma, and liver cirrhosis

Figure 1 Positron emission tomography imaging study on a 75-year-old man with hepatocellular carcinoma. ¹⁸F-Fludeoxyglucose (FDG) and ⁶⁸Ga-prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography imaging was performed. A: Maximal intensity projection, ⁶⁸Ga-PSMA revealed focal uptake [bold orange arrow, standardized uptake value (SUV)max: 7.6; black arrow, SUVmax: 5.7]; B: Maximal intensity projection, ¹⁸F-FDG revealed focal uptake (bold white arrow, SUVmax: 4.6), no uptake in right lesion (white arrow); C: Gross section displayed a nodule histologically classified as hepatocellular carcinoma; D: Strong PSMA expression (400 ×, immunohistochemistry, scale bar = 100 μm) was shown in the tumor-associated vascular; E and G: Transaxial fused, ⁶⁸Ga-PSMA revealed focal uptake (bold black arrow, SUVmax: 7.6; black arrow, SUVmax: 5.7); F and H: Transaxial fused, ¹⁸F-FDG revealed focal uptake (bold white arrow, SUVmax: 4.6), no uptake in right lesion (white arrow).