Clinical features of multiple gastrointestinal stromal tumors: A pooling analysis combined with evidence and gap map

Table 2 Tumor and pathological features of patients with multiple gastrointestinal stromal tumors, n (%)

	PKUPH patients, n = 121	Literature-based patients, n = 1611	Total patients, n = 1731
Site	n = 40	n = 330	n = 370
Stomach	22 (55.00)	121 (36.67)	143 (38.65)
Small intestine	17 (42.50)	201 (60.91)	218 (58.92)
Duodenum	1 (2.50)	27 (8.18)	28 (7.57)
Jejunum	4 (10.00)	68 (20.61)	72 (19.46)
Ileum	3 (7.50)	25 (7.58)	28 (7.57)
Other sites	1 (2.50)	8 (2.42)	9 (2.43)
Involving organ	n = 12	n = 156	n = 168
Single	9 (75.00)	108 (69.23)	117 (69.64)
Two or more	3 (25.00)	48 (30.77)	51 (30.36)
Size in cm	n = 40	n = 315	n = 355
Range	0.10-8.00	0.05-27.00	0.05-27.00
≤ 1	22 (55.00)	94 (29.84)	116 (32.68)
1-2	4 (10.00)	65 (20.64)	69 (19.44)
2-5	11 (27.75)	98 (31.11)	109 (30.70)
5-10	3 (7.50)	45 (14.29)	48 (13.52)
> 10	0 (0.00)	13 (4.13)	13 (3.56)
Mean (SD)	2.00 (2.16)	3.26 (3.50)	3.12 (3.40)
Cellular type	n = 40	n = 180	n = 220
Spindle	40 (100.00)	137 (76.11)	177 (80.46)
Epithelial	0 (0.00)	23 (12.78)	23 (10.46)
Mixed	0 (0.00)	20 (11.11)	20 (9.09)
Mitosis, /50 HPFs	n = 35	n = 202	n = 237
Range	0-9	0-48	0-48
≤ 5	33 (94.29)	174 (86.14)	207 (87.34)
5-10	2 (5.71)	15 (7.43)	17 (7.17)
> 10	0 (0.00)	13 (6.44)	13 (5.49)
Mean (SD)	3.86 (1.87)	3.32 (5.91)	3.40 (5.50)
Risk classification	n = 35	n = 249	n = 284
Very low risk	20 (57.14)	54 (21.69)	74 (26.05)
Low risk	10 (28.57)	113 (45.38)	123 (43.31)
Median risk	3 (8.57)	26 (10.44)	29 (10.21)
High risk	2 (5.71)	56 (22.49)	58 (20.42)
CD117	n = 35	n = 149	n = 184
Positive	35 (100.00)	144 (96.64)	179 (97.28)
CD34	n = 35	n = 140	n = 175
Positive	12 (34.29)	114 (81.43)	126 (72.00)
Ki-67	n = 35	n = 47	n = 82
Range	0-20	1-33.8	0-33.8
Mean (SD)	3.83 (4.85)	3.96 (5.11)	3.91 (4.97)
Desmin	n = 35	n = 98	n = 133
Positive	1 (2.86)	1 (1.02)	2 (1.50)
S-100	n = 35	n = 108	n = 143
Positive	1 (2.86)	32 (29.63)	33 (23.08)
SMA	n = 35	n = 120	n = 155
Positive	5 (14.29)	19 (15.83)	24 (15.48)

¹n For total number of patients, other n for number of patients with relevant data. HPFs: High-power fields; PKUPH: Peking University People’s Hospital; SD: Standard deviation.